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1.
Psicol. ciênc. prof ; 43: e249888, 2023.
Article in Portuguese | LILACS, INDEXPSI | ID: biblio-1422426

ABSTRACT

A recomendação ética do psicólogo para intervir criticamente sobre a demanda vai de encontro com a tarefa de diagnosticar atos de Alienação Parental e, num sentido amplo, com a judicialização das relações privadas. A genealogia de Foucault consiste num método capaz de lançar luz sobre as práticas de poder na base dos discursos relacionados ao tema da alienação parental. O eufemismo pedagógico empregado para designar as sanções da lei tem como finalidade estratégica o convencimento a respeito de supostos benefícios da tutela sobre as famílias, ao mesmo tempo em que lhes são atribuídas alguma patologia disfuncional. Numa perspectiva crítica, a assimetria de gêneros corresponde às relações de poder presentes no problema da alienação parental. Por fim, a inversão dos critérios de identificação da alienação parental revela o distanciamento entre o ideal normativo e a realidade da ruptura conjugal e familiar, apontando para a importância de práticas de cuidado e assistência em vez de judicativas e punitivas.(AU)


The psychologist's ethical recommendation to critically intervene on the demand goes against the task of diagnosing acts of Parental Alienation (AP) and, in a broad sense, with the judicialization of private relations. Foucault's genealogy consists of a method able to shed on the power practices on the basis of discourses related to the theme of Parental Alienation. The pedagogical euphemism used to designate the sanctions of the law has the strategic purpose of convincing about the supposed benefits of guardianship over families, while attributing some dysfunctional pathology to them. From a critical perspective, gender asymmetry corresponds to the power relations present in the Parental Alienation problem. Finally, the inversion of the Parental Alienation's identification criteria reveals the gap between the normative ideal and the reality of marital and family disruption, pointing to the importance of care and assistance practices instead of judicative and punitive ones.(AU)


La recomendación ética del psicólogo de intervenir críticamente sobre la demanda va en contra de la tarea de diagnosticar actos de Alienación Parental (AP) y, en un sentido amplio, con la judicialización de las relaciones privadas. La genealogía de Foucault consiste en un método capaz de arrojar luz sobre las prácticas del poder a partir de discursos relacionados con el tema de la Alienación Parental. El eufemismo pedagógico que se utiliza para designar las sanciones de la ley tiene el propósito estratégico de convencer sobre los supuestos beneficios de la tutela sobre las familias, atribuyéndoles alguna patología disfuncional. Desde una perspectiva crítica, la asimetría de género corresponde a las relaciones de poder presentes en el problema de la Alienación Parental. Finalmente, la inversión de los criterios de identificación de la Alienación Parental revela la brecha entre el ideal normativo y la realidad de la ruptura conyugal y familiar, señalando la importancia de las prácticas de cuidado y asistencia en lugar de las judicativas y punitivas.(AU)


Subject(s)
Humans , Male , Female , Social Justice , Child Custody , Genealogy and Heraldry , Jurisprudence , Anxiety , Psychoanalysis , Public Policy , Repression, Psychology , Attention Deficit Disorder with Hyperactivity , Socioeconomic Factors , Therapeutics , Behavior and Behavior Mechanisms , Child Abuse, Sexual , Adaptation, Psychological , Divorce , Marriage , Child Abuse , Child Advocacy , Child Development , Child Rearing , Child Welfare , Mental Health , Liability, Legal , Negotiating , Domestic Violence , Spouses , Feminism , Single-Parent Family , Culture , State , Damage Liability , Whistleblowing , Dissent and Disputes , Depression , Dissociative Disorders , Employment , Family Conflict , Family Relations , Fathers , Resilience, Psychological , Forgiveness , Sexism , Physical Abuse , Gender-Based Violence , Social Oppression , Gender Stereotyping , Adverse Childhood Experiences , Family Separation , Sadness , Betrayal , Models, Biopsychosocial , Gender Equity , Gender Role , Family Support , Family Structure , Helplessness, Learned , Human Rights , Interpersonal Relations , Learning Disabilities , Mothers , Dissociative Identity Disorder , Object Attachment
2.
Psicol. ciênc. prof ; 43: e262380, 2023.
Article in Portuguese | LILACS, INDEXPSI | ID: biblio-1529226

ABSTRACT

Este artigo apresenta como principal objeto de estudo a falsa acusação de abuso sexual no contexto da alienação parental para, diante dela, estabelecer a seguinte problemática: será possível propor uma eventual correlação entre si e os processos psíquicos do luto e da melancolia? Neste sentido, a partir do recurso teórico ao referencial psicanalítico de Freud e de Laplanche, debate as circunstâncias que norteiam o discurso levado ao Judiciário pelo genitor alienante valorizando em tal movimento não apenas a realidade material da prova, tão importante no campo jurídico, mas também a realidade psíquica ditada pelo inconsciente, a qual se pauta em uma noção de verdade que, na sua vinculação direta com a particularidade de cada sujeito e com o dinamismo das relações específicas que ele estabelece consigo mesmo e com os outros, coloca em xeque as certezas positivistas da norma. Em termos conclusivos, destaca o quanto, a despeito da atual literatura existente sobre alienação parental no Brasil a correlacionar, em regra, a um luto mal elaborado por parte do alienante, é possível e mesmo desejável cogitar também a presença da melancolia - ou, mais especificamente, de traços melancólicos intermediários - na formação e desenvolvimento desse fenômeno.(AU)


This article presents as the main object of study the false accusation of sexual abuse in the context of parental alienation, to establish the following problem: would it be possible to propose a probable correlation between parental alienation and the psychic processes of mourning and melancholia? In this sense, based on the psychoanalytic theoretical framework of Freud and Laplanche, the article discusses the circumstances that guide the discourse taken to the judiciary branch by the alienating parent, valuing in such action not only the material reality of the evidence, which is very important in the legal field, but also the psychic reality dictated by the unconscious, which is guided by a notion of truth that, in its direct connection with the particularity of each subject and with the dynamism of the specific relations that they establish with themselves and others, threatens the positivist certainties of the norm. In conclusive terms, it highlights how, despite the current existing literature on parental alienation in Brazil generally correlates it to a poorly elaborated mourning by the alienating person, it is possible and even desirable to also consider the presence of melancholia-or, more specifically, of intermediate melancholic traits-in the formation and development of this phenomenon.(AU)


Este artículo presenta como principal objeto de estudio la falsa acusación de abuso sexual en el contexto de alienación parental, con el fin de responder al siguiente planteamiento: ¿Es posible proponer una posible correlación entre la alienación parental y los procesos psíquicos de duelo y melancolía? Para ello, desde el marco psicoanalítico de Freud y de Laplanche, se discuten las circunstancias del discurso llevado al Poder Judicial por el padre alienante, que valora en tal movimiento no solo la realidad material de la prueba, tan importante en el campo jurídico, sino también la realidad psíquica dictada por el inconsciente, el cual se guía por una noción de verdad que, en su conexión directa con la particularidad de cada sujeto y con el dinamismo de las relaciones específicas que establece consigo mismo y con otros, pone en jaque las certezas positivistas de la norma. En la conclusión, destaca cómo, a pesar de la literatura actual existente sobre la alienación parental en Brasil, en general, la correlaciona con un duelo mal diseñado por parte de la persona alienante, es posible e incluso deseable considerar la presencia de la melancolía -más específicamente, de rasgos melancólicos intermediarios- en la formación y desarrollo de este fenómeno.(AU)


Subject(s)
Humans , Male , Female , Sex Offenses , Social Alienation , Bereavement , False Representation , Depressive Disorder , Deception , Parent-Child Relations , Paternal Behavior , Paternal Deprivation , Pedophilia , Psychology , Psychology, Social , Public Policy , Rape , Rejection, Psychology , Repression, Psychology , Repression-Sensitization , Scapegoating , Self-Assessment , Self Concept , Shame , Social Justice , Social Sciences , Spouse Abuse , Suicide , Therapeutics , Unconscious, Psychology , Child Abuse, Sexual , Child Custody , Divorce , Family , Marriage , Child , Child, Abandoned , Child Advocacy , Child Care , Child Rearing , Child Welfare , Mental Health , Risk Factors , Adolescent , Parenting , Codependency, Psychological , Marital Status , Domestic Violence , Sexuality , Crime , Disasters Consequence Analysis , Surveillance in Disasters , Textbook , Defense Mechanisms , Whistleblowing , Trust , Aggression , Dependency, Psychological , Reproductive Rights , Diagnosis , Double Bind Interaction , Emotions , Ethics , Expert Testimony , Family Conflict , Family Relations , Fear , Apathy , Defamation , Physical Abuse , Fraud , Freedom , Freudian Theory , Forensic Psychology , Frustration , Disgust , Sadness , Respect , Psychological Distress , Betrayal , Emotional Abuse , Citizenship , Guilt , Hate , Hostility , Human Rights , Judgment , Jurisprudence , Love , Malpractice , Morale , Mothers , Narcissism , Object Attachment
3.
Psicol. ciênc. prof ; 43: e263291, 2023.
Article in Portuguese | LILACS, INDEXPSI | ID: biblio-1529215

ABSTRACT

Este artigo tem como objetivo produzir uma análise histórica sobre as intersecções entre Psicologia e sexualidade desviantes da norma no Brasil, de fins do século XIX a meados da década de 1980. Esta temporalidade foi escolhida por abarcar o surgimento das pesquisas científicas sobre sexualidade e desvios sexuais, a consolidação dos estudos psicológicos sobre a temática e o processo mais recente de despatologização da homossexualidade. Em termos teóricos e metodológicos, foram adotados os pressupostos da História Social da Psicologia e da historiografia das homossexualidades no Brasil. Desse modo, buscou-se compreender como as ideias, concepções e práticas psicológicas foram mudando ao longo do tempo, em conexão com as transformações socioculturais e políticas que ocorreram durante o século XX. Para isto, foram utilizadas fontes primárias e secundárias de pesquisa com vistas à produção de interpretações sobre as conexões entre as ideias, os atores e os eventos narrados. Argumenta-se, ao longo do artigo, que as ideias e práticas psicológicas estão intrinsecamente conectadas aos contextos socioculturais e políticos de seu tempo, sendo os movimentos dinâmicos e os conflitos presentes nesses contextos fatores determinantes para a sua constituição.(AU)


This article aims to produce a historical analysis of the intersections between Psychology and sexualities that deviate from the norm in Brazil, from the late 19th century to the mid-1980s. This period was chosen because it encompasses the emergence of scientific research on sexuality and sexual deviations, the consolidation of psychological studies on the subject and the most recent process of de-pathologization of homosexuality. Theoretically and methodologically, the assumptions of the Social History of Psychology and the historiography of homosexualities in Brazil were adopted. Therefore, we sought to understand how psychological ideas, conceptions and practices have changed over time, in connection with the sociocultural and political transformations that occurred throughout the 20th century. For this, primary and secondary sources of research were used to produce interpretations about the connections between the ideas, the actors and the narrated events. It is argued, throughout the article, that the psychological ideas and practices are intrinsically connected to the sociocultural and political contexts of their time, being the dynamic movements and conflicts present in these contexts determining factors for their constitution.(AU)


Este artículo tiene como objetivo realizar un análisis histórico de las intersecciones entre la Psicología y las sexualidades desviadas de la norma en Brasil desde finales del siglo XIX hasta mediados de la década de 1980. Esta temporalidad fue elegida por abarcar el surgimiento de las investigaciones científicas sobre sexualidad y desvíos sexuales, la consolidación de los estudios psicológicos sobre el tema y el más reciente proceso de despatologización de la homosexualidad. En el marco teórico y metodológico, se adoptaron los presupuestos de la Historia Social de la Psicología y de la historiografía de las homosexualidades en Brasil. De esta manera, se pretende comprender cómo las ideas, concepciones y prácticas psicológicas han cambiado a lo largo del tiempo, en conexión con las transformaciones socioculturales y políticas ocurridas durante el siglo XX. Para ello, se utilizaron las fuentes de investigación primarias y secundarias con miras a generar interpretaciones sobre las conexiones entre las ideas, los actores y los eventos narrados. Se argumenta, a lo largo de este artículo, que las ideas y las prácticas psicológicas están intrínsecamente conectadas a los contextos socioculturales y políticos de su tiempo, y los movimientos dinámicos y los conflictos presentes en estos contextos fueron los factores determinantes para su constitución.(AU)


Subject(s)
Humans , Male , Female , Brazil , Homosexuality , Sexuality , History , Orgasm , Paraphilic Disorders , Pathology , Pedophilia , Personality Development , Personality Disorders , Pleasure-Pain Principle , Psychology , Psychosexual Development , Public Policy , Rationalization , Religion and Sex , Repression, Psychology , Sadism , Sex , Sexual Behavior , Disorders of Sex Development , Sex Offenses , Social Control, Formal , Social Environment , Societies , Avoidance Learning , Sublimation, Psychological , Taboo , Therapeutics , Transvestism , Unconscious, Psychology , Voyeurism , Behavior Therapy , Child Abuse, Sexual , Attitude , Character , Christianity , Mental Competency , Sexual Harassment , Coitus , Human Body , Homosexuality, Female , Conflict, Psychological , Community Participation , Cultural Diversity , Feminism , Heterosexuality , Neurobehavioral Manifestations , Sexual Dysfunctions, Psychological , Crime , Cultural Characteristics , Culture , Safe Sex , Mind-Body Therapies , Defense Mechanisms , Dehumanization , Human Characteristics , Intention , Moral Development , Emotions , Health Research Agenda , Discussion Forums , Population Studies in Public Health , Eugenics , Exhibitionism , Pleasure , Fetishism, Psychiatric , Sexual Health , Homophobia , Racism , Social Marginalization , Medicalization , Transgender Persons , Moral Status , Sexual and Gender Minorities , Political Activism , Gender Diversity , Asexuality , Undisclosed Sexuality , Sexuality Disclosure , Gender Norms , Gender Blind , Androcentrism , Freedom , Freudian Theory , Respect , Gender Identity , Sexual Trauma , Workhouses , Psychosocial Functioning , Gender Role , Intersectional Framework , Family Structure , Health Promotion , Human Development , Human Rights , Identification, Psychological , Anatomy , Disruptive, Impulse Control, and Conduct Disorders , Incest , Instinct , Introversion, Psychological , Libido , Masochism , Masturbation , Mental Disorders , Methods , Morale , Morals , Neurotic Disorders
4.
Psicol. ciênc. prof ; 43: e248134, 2023.
Article in Portuguese | LILACS, INDEXPSI | ID: biblio-1422408

ABSTRACT

O presente artigo é oriundo de pesquisa acadêmica que teve como objetivo estudar a clínica psicanalítica e seus efeitos por meio da apresentação de fragmentos de uma análise já encerrada. Para alcançar esse objetivo, utilizamos a ferramenta metodológica do fato clínico, articulando o material clínico com alguns pontos da teoria psicanalítica. Como resultado, apontamos que é possível fazer uma leitura teórico-clínica de uma experiência de análise sob a perspectiva dos movimentos discursivos, em especial do sujeito do inconsciente ($) e do objeto a, conforme apresentados na proposição dos Quatro Discursos de Lacan. Acreditamos que este estudo enfatiza a importância da especificidade da pesquisa em psicanálise em sua dimensão clínica e os possíveis efeitos produzidos por esse processo terapêutico. Dessa maneira, entendemos que a divulgação deste trabalho pode contribuir para a discussão da prática clínica entre colegas do campo psicanalítico e acadêmico, bem como para a difícil tarefa da apresentação do material clínico com a sustentação teórica necessária, a fim de fortalecermos a sempre fundamental transmissão da psicanálise.(AU)


This article comes from academic research that aimed to study the psychoanalytic clinic and its effects by presenting fragments of an analysis that has already ended. To achieve this goal, we used the methodological tool of the clinical fact, articulating the clinical material with some points of psychoanalytic theory. As a result, we point out that it is possible to make a theoretical-clinical reading of an analysis experience from the perspective of discursive movements, in particular, the subject of the unconscious ($) and of the object a, as presented in the proposition of Lacan's Four Discourses. We believe that this study emphasizes the importance of the specificity of research in psychoanalysis in its clinical dimension and the possible effects produced by this therapeutic process. In this way, we understand that the dissemination of this work can contribute to the discussion of clinical practice among colleagues in the psychoanalytic and academic fields, as well as to the difficult task of presenting clinical material with the necessary theoretical support, to strengthen the always fundamental transmission of psychoanalysis.(AU)


Este artículo surge de una investigación académica que pretendió estudiar la clínica psicoanalítica y sus efectos mediante la presentación de fragmentos de un análisis que ya terminó. Para lograr este objetivo, se utilizó la herramienta metodológica del hecho clínico articulando el material clínico con algunos puntos de la teoría psicoanalítica. El resultado permite señalar que es posible realizar una lectura teórico-clínica de una experiencia de análisis desde la perspectiva de los movimientos discursivos, en particular el sujeto del inconsciente ($) y el objeto a, como se presenta en la proposición de los cuatro discursos de Lacan. Este estudio enfatiza la importancia de la especificidad de la investigación en psicoanálisis en su dimensión clínica y los posibles efectos que produce este proceso terapéutico. De esta forma, la difusión de este trabajo puede contribuir a la discusión de la práctica clínica entre colegas del campo psicoanalítico y académico, así como a la difícil tarea de presentar material clínico con el soporte teórico necesario para fortalecer la siempre fundamental transmisión del psicoanálisis.(AU)


Subject(s)
Humans , Psychoanalysis , Truth Disclosure , Practice Guideline , Address , Methodology as a Subject , Anxiety , Pathology , Personal Satisfaction , Phobic Disorders , Psychology , Rabies , Repression, Psychology , Self Concept , Shame , Sublimation, Psychological , Superego , Tachycardia , Unconscious, Psychology , Family , Panic Disorder , Sexuality , Death , Dependent Personality Disorder , Depersonalization , Dizziness , Education , Ego , Pleasure , Free Association , Adverse Childhood Experiences , Sadness , Psychological Distress , Hysteria , Id , Instinct , Libido , Linguistics , Loneliness , Oedipus Complex
5.
Psicol. ciênc. prof ; 43: e249352, 2023.
Article in Portuguese | LILACS, INDEXPSI | ID: biblio-1422397

ABSTRACT

Com este estudo buscou-se conhecer as dificuldades e barreiras de pais na educação sexual de jovens com Síndrome de Down, a partir de uma pesquisa descritiva e de natureza qualitativa, utilizando-se o conceito das representações sociais como referencial teórico-metodológico. O estudo foi conduzido em uma Organização Não Governamental (ONG), localizada em Recife (PE), após aprovação do Comitê de Ética e Pesquisa, sob parecer consubstanciado 3.558.587. A amostra do estudo envolveu 11 pais de jovens com Síndrome de Down com idades entre 15 e 24 anos. A coleta de dados foi realizada por meio de entrevistas semiestruturadas. A abordagem escolhida para a interpretação desses dados foi a análise de conteúdo proposta por Bardin. Pode-se elencar como principais dificuldades enfrentadas pelos pais ao conversarem com seus filhos sobre sexualidade: a infantilização do jovem com Síndrome de Down, julgando-o incapaz de experienciar tais fenômenos e compreender a orientação que pudesse ser repassada; o medo em ultrapassar etapas e, de repente, "estimular" o filho a viver sua sexualidade de maneira "precoce"; e o fato de os pais também terem recebido pouca ou nenhuma orientação sexual por parte de suas famílias. Diante das narrativas dos pais, é possível perceber que ainda são muitos os mitos, tabus e preconceitos que permeiam a sexualidade dos jovens com Síndrome de Down, demonstrando que os responsáveis estão despreparados para dar as devidas orientações.(AU)


This study sought to know the difficulties and barriers of parents in the sexual education of young people with Down Syndrome, from a descriptive, qualitative study, using the concept of social representations as a theoretical-methodological framework. The study was conducted in a Non-Governmental Organization (NGO), located in Recife (PE) after approval by the Ethics and Research Committee, under substantiated opinion 3,558,587. The study sample involved 11 parents of young people with Down Syndrome aged between 15 and 24 years. The data collection was carried out by using semi-structured interviews. The approach chosen for interpretation of these data was the content analysis proposed by Bardin. The main difficulties faced by parents in talking with their children about sexuality can be listed as: the infantilization of young persons with Down Syndrome, deeming them incapable of experiencing such phenomena and understanding the guidance that could be given; the fear of overshooting the stages and, suddenly, "stimulating" the child to live their sexuality in an "early" way; and the facts of the parents also having received little or no sexual guidance from their families. Given the parents' narratives, it is possible to realize that there are still many myths, taboos, and prejudices that permeate the sexuality of young people with Down Syndrome, demonstrating that parents were unprepared to provide the right guidance.(AU)


Este estudio buscó conocer las dificultades y barreras de los padres en la educación sexual de los jóvenes con síndrome de Down a partir de un estudio descriptivo, cualitativo, que utilizó el concepto de representaciones sociales como marco teórico-metodológico. La investigación se llevó a cabo en una Organización No Gubernamental (ONG), ubicada en la ciudad de Recife (Pernambuco, Brasil), después de la aprobación del Comité de Ética e Investigación, bajo la opinión fundamentada 3.558.587. La muestra del estudio incluyó a 11 padres de jóvenes con síndrome de Down con edades comprendidas entre 15 y 24 años. La recolección de datos se realizó mediante entrevista semiestructurada. El enfoque elegido para la interpretación de los datos fue el análisis de contenido propuesto por Bardin. Pueden enumerarse como las principales dificultades que enfrentan los padres para hablar sobre la sexualidad con sus hijos: la infantilización del joven con síndrome de Down, considerándolo incapaz de experimentar tales fenómenos y comprender la orientación que se le puede dar; el miedo de ir más allá de las etapas y, de repente, "estimular" al niño a vivir su sexualidad de una manera "temprana"; y el hecho de que los padres también habían recibido poca o ninguna orientación sexual de sus familias. Dadas las narraciones de los padres, es posible darse cuenta de que todavía hay muchos mitos, tabúes y prejuicios sobre la sexualidad de los jóvenes con síndrome de Down, lo que muestra que los padres no estaban preparados para brindarles este tipo de orientación.(AU)


Subject(s)
Humans , Male , Female , Adolescent , Young Adult , Parents , Sex Education , Down Syndrome , Sexuality , Psychology , Repression, Psychology , Sex , Shame , Biology , Puberty , Privacy , Social Integration , Hormones , Acculturation , Libido , Masturbation
7.
Psicol. ciênc. prof ; 42: e242969, 2022.
Article in Portuguese | LILACS, INDEXPSI | ID: biblio-1422387

ABSTRACT

Este artigo tem como objetivo trabalhar com a concepção de "conhecimento encarnado" defendida por Ignácio Martín-Baró, estabelecendo relações entre este conceito e o campo da Psicologia Social. Num primeiro momento, fazemos uma pequena contextualização dos efeitos de uma greve universitária que durou quatro meses, considerando que os principais efeitos que devemos debater são aqueles que estão relacionados às experimentações do espaço educacional, assim como às ressonâncias das narrativas externas ao mundo universitário. Em seguida, mesclamos experiências do cotidiano da universidade com narrativas de diferentes atores sociais sobre a greve e a própria formação, a fim de desenvolver uma teoria analítica das práticas educacionais em Psicologia Social a partir de um diálogo com Ignácio Martín-Baró. Destacamos as três perguntas apresentadas pelo autor para problematizar a história da Psicologia Social: o que nos mantém unidos numa ordem social? O que nos integra à ordem estabelecida? O que nos libera da desordem estabelecida? Entre os diferentes conceitos criados pelo autor, privilegiamos a ideia de conhecimento encarnado, realidade vivida, realidade estudada e ação ideológica.(AU)


This article aims to work with the conception of "incarnate knowledge" defended by Ignácio Martin-Baró establishing relationships between this concept and the field of Social Psychology. At first, we briefly contextualize the effects of a strike in the university environment that lasted four months, considering that the main effects that we should debate are those related to experimentations of the educational space and the resonances of the external narratives in the university world. Then, we blended experiences of the university's quotidian with narratives of different social actors about the strike and the training itself to develop an analytic theory of the educational practices in Social Psychology from a dialog with Ignácio Martin-Baró. We highlight three questions presented by the author to challenge the history of Social Psychology: what holds us together in a social order? What integrates us into the established order? What frees us from the established disorder? Among the different concepts created by the author, we privileged the idea of incarnate knowledge, lived reality, studied reality, and ideological action.(AU)


Este artículo pretende trabajar con la concepción de conocimiento defendida por Ignácio Martín-Baró, estableciendo relaciones entre este conocimiento y el campo de la psicología social. En un primer momento, hacemos una pequeña contextualización de los efectos de una huelga universitaria, que tuvo una duración de cuatro meses, considerando que los principales efectos los cuales debemos debatir son aquellos que están relacionados con las experimentaciones del espacio educacional, así como las resonancias de las narrativas externas al mundo universitario. A continuación, mezclamos experiencias de un cotidiano de la universidad con narrativas de diferentes actores sociales sobre la huelga y la propia formación, con la finalidad de desarrollar una teoría analítica de las prácticas educacionales en la psicología social a partir de un diálogo con Ignácio Martin-Baró. Destacamos las tres preguntas presentadas por el autor para problematizar la historia de la psicología social: ¿Qué nos mantiene unidos en el orden social establecido? ¿Qué nos integra al orden establecido? ¿Qué nos libera del desorden establecido? Entre los diferentes conceptos creados por el autor, privilegiamos la idea de un conocimiento encarnado, realidad vivida, realidad estudiada y acción ideológica.(AU)


Subject(s)
Humans , Male , Female , Psychology, Social , Teaching , Knowledge , Education , Persuasive Communication , Philosophy , Politics , Psychology , Repression, Psychology , Social Conformity , Social Problems , Socioeconomic Factors , Strikes, Employee , Universities , Work , Comment , Letter , Civil Rights , Conflict, Psychological , Guideline Adherence , Africa , Personal Autonomy , Comprehension , Environment , Science, Technology and Society , Ethics , Faculty , Indigenous Culture , Respect , Corruption , Functional Status , Information Motivation Behavioral Skills Model , History , Human Rights , Machiavellianism
8.
Pesqui. prát. psicossociais ; 16(2): 1-16, maio-ago. 2021. tab
Article in Portuguese | LILACS, INDEXPSI | ID: biblio-1351243

ABSTRACT

Este trabalho é fruto de uma investigação histórica sobre as condições da emergência do grupo do Setor de Psicologia Social da Universidade Federal de Minas Gerais, bem como o desenvolvimento de suas atividades. Tomamos como abordagem metodológica a análise documental, além de entrevistas, com foco no período 1964-1994, estando este marcado por uma grande repressão política que, todavia, não silenciou um debate crítico, o que levou o Setor a ter uma grande contribuição para a institucionalização e fortalecimento da Psicologia Social no Brasil. O intuito é examinar a proposição do Setor a partir das disciplinas ofertadas e entender a diversidade de seus temas, o intercâmbio de pesquisadores e alunos com outras universidades, além da internacionalização desse projeto, incluindo grupos franceses, enfatizando a sua contribuição para a disseminação e consolidação da Psicossociologia.


This paper is the result of a historical investigation about the conditions of the emergence of the Social Psychology Sector of the Universidade Federal de Minas Gerais as well as the development of its activities. We took as methodological approach, the documental analysis besides interviews and with focus on the period 1964-1994, which was marked by a great political repression, that nevertheless did not silence a critical debate, which led the Sector to have a great contribution to the institutionalization and strengthening of Social Psychology in Brazil. The purpose is to examine the proposal of the sector from the disciplines offered and to understand the diversity of its themes, the interchange of researchers and students with other universities and the internationalization of this project including French groups, emphasizing its contribution to the dissemination and consolidation of Psychosociology.


Este trabajo es el resultado de una investigación histórica sobre las condiciones del surgimiento del Sector de Psicología Social de la Universidade Federal de Minas Gerais, así como el desarrollo de sus actividades. Nuestro enfoque metodológico se basó en el análisis documental y las entrevistas, centrándose en el período 1964-1994, que estuvo marcado por una gran represión política, pero que no silenció el debate crítico, y que llevó al Sector a hacer una gran contribución a la institucionalización y fortalecimiento de la Psicología Social en Brasil. El propósito es examinar la propuesta del sector desde las disciplinas ofrecidas y comprender la diversidad de sus temas, el intercambio de investigadores y estudiantes con otras universidades y la internacionalización de este proyecto incluyendo grupos franceses, destacando su contribución a la difusión y consolidación de la Psicosociología.


Subject(s)
Psychology, Social , Politics , Psychology/history , Repression, Psychology , Universities , Institutionalization
9.
Rev. latinoam. cienc. soc. niñez juv ; 19(1): 176-203, ene.-abr. 2021.
Article in Spanish | LILACS | ID: biblio-1251882

ABSTRACT

Resumen (analítico) En este artículo analizamos la participación de los jóvenes en los movimientos alteractivistas de 2011 y los estallidos sociales de 2019, quienes, al parecer, han sido protagonistas de nuevas formas de acción colectiva y conectiva. Desde el enfoque cualitativo de investigación y el método de análisis documental, se revisó un corpus de 61 documentos que comprenden literatura académica e información mediática sobre estos hechos. En los resultados se destacan: la redefinición ontológica y sociopolítica de la condición juvenil a partir de la acción colectiva; el tránsito de prácticas políticas antiglobalización a repertorios de acción colectiva más radicales que buscan resistir a la precariedad y la violencia; y acciones conectivas que transitan de estrategias de replicación a intercambios entre gestores de contenidos y audiencias, por medio de textos multimodales-performativos.


Abstract (analytical) In this article we analyze the participation of young people in the alteractivist movements of 2011 and the social outbreaks of 2019, who, apparently, have been protagonists of new forms of collective and connective action. From the qualitative research approach and the documentary method, we check a corpus of 61 documents about academic literature and media information. The results show: the ontological and sociopolitical redefinition of the youth condition based on collective action; the transition from anti-globalization political practices to more radical repertoires of collective action that seek to resist precariousness and violence; and connective actions that go from replication strategies to exchanges between content managers and audiences, through multimodal-performative texts.


Resumo (analítico) Neste artigo, analisamos a participação dos jovens nos movimentos alterativistas de 2011 e os surtos sociais de 2019, que, aparentemente, foram protagonistas de novas formas de ação coletiva e conectiva. A partir da abordagem qualitativa da pesquisa e do método de análise documental, foi revisado um corpus de 61 documentos que compõem a literatura acadêmica e informações midiáticas sobre esses eventos. Destacam-se os resultados: a redefinição ontológica e sociopolítica da condição juvenil a partir da ação coletiva; a transição das práticas políticas antiglobalização para repertórios mais radicais de ação coletiva que buscam resistir à precariedade e à violência; e ações conectivas que vão desde estratégias de replicação até trocas entre gestores de conteúdo e públicos, por meio de textos multimodal-performativos.


Subject(s)
Poverty , Adolescent , Repression, Psychology , Social Participation
10.
Rev. psicanal ; 27(3): 697-713, Dezembro 2020.
Article in Portuguese | LILACS, INDEXPSI | ID: biblio-1252807

ABSTRACT

O artigo pretende ampliar a ideia freudiana de que os elementos do sentimento da inquietante estranheza são resultantes do trabalho do recalque. Pretendemos esboçar um possível entrelaçamento entre o que Freud propõe pensarmos como O estranho, a sexualidade infantil e o sexual primordial, relacionando estes aspectos com as nossas dificuldades, como psicanalistas, de pensar e debater temas cada vez mais presentes na realidade do homem do século XXI: as pluralidades e as diversidades da sexualidade (AU)


The article intends to expand the Freudian idea that the elements of the feeling of uncanny strangeness result from the work of repression. We intend to outline a possible weaving between what Freud proposes to think of as The stranger, child sexuality and primordial sexual, relating these aspects to our difficulties, as psychoanalysts, to think and debate themes increasingly present in the reality of the 21st century people: the pluralities and diversities of sexuality (AU)


El artículo pretende ampliar la idea freudiana de que los elementos del sentimiento de inquietante extrañeza son el resultado del trabajo de represión. Pretendemos esbozar un posible vínculo entre lo que Freud propone pensar como El extraño, la sexualidad infantil y la sexualidad primordial, relacionando estos aspectos con nuestras dificultades, como psicoanalistas, de pensar y debatir temas cada vez más presentes en la realidad del hombre del siglo XXI: las pluralidades y diversidades de la sexualidad (AU)


Subject(s)
Repression, Psychology , Sexuality , Neurotic Disorders
11.
Rev. colomb. psiquiatr ; 49(2): 121-126, abr.-jun. 2020. tab
Article in English | LILACS, COLNAL | ID: biblio-1115653

ABSTRACT

ABSTRACT In 2018 the academy will celebrate the 200th anniversary of the publication of the seminal work of Arthur Schopenhauer (1788-1860): The World as Will and Representation (Idea). Schopenhauer is known as the "philosopher of pessimism" and as the "psychologist of the will". His thinking is formally absent in the psychiatric education curricula, which could be enriched by the philosopher's work. Regarding psychiatry's theoretical foundations, Schopenhauer: a) anticipated several issues of species' origin and evolution, which are used in the contemporary understanding of disease development; b) anticipated some attributes of the psychodynamic and cognitive unconscious when referring to the irrational features of the will; c) foresaw the current concept of the embodied mind, which emphasizes the role of the body's structure and dynamics in cognition instead of that of a transcendental reason; d) proposed a simplified and heuristic model of mind, comprising the senses, understanding and reason; at a pragmatic level, particularly concerning psychotherapy, the philosopher e) stated that all human actions spring from three fundamental sources: egoism, malice and compassion; he also speculated about the role of unconscious repression in the genesis of mental illnesses; and finally, f) emphasized the ubiquity of suffering and the insatiability of desire, which unavoidably leads to egocentrism. In this regard he highly valued contemplation of art and nature as a way of dissociating knowledge from desire, and thus allowing the development of compassion and asceticism. This was considered by the philosopher to be "denial of the will", and a path for individual salvation and well-being. In contemporary psychiatry, this metaphysical proposal may be reformulated in terms of promoting cooperation and healthy austerity as a non-specific component of most psychotherapies and educational models. Schopenhauer's thinking may enrich psychiatric training and personal well-being.


RESUMEN En 2018 la academia celebra el bicentenario de la publicación de la obra capital de Arthur Schopenhauer (1788-1860) El mundo como voluntad y representación (idea). Schopenhauer es conocido como el «filósofo pesimista¼ y el «psicólogo de la voluntad¼. Su obra está formalmente ausente en el currículo de la formación en Psiquiatría, que puede enriquecerse con las siguientes contribuciones del filósofo. Con relación a los fundamentos teóricos de la Psiquiatría, Schopenhauer: a) anticipó diversos aspectos del origen y la evolución de las especies que hoy se utilizan para la comprensión del desarrollo de la enfermedad; b) anticipó algunos atributos del inconsciente dinámico y cognitivo cuando se refirió a los aspectos no racionales de la voluntad; c) predijo el concepto contemporáneo de la mente corporizada, cuando enfatizó con relación a la cognición el papel de la estructura y la dinámica corporales, en lugar de una razón trascendental; d) propuso un modelo simplificado y heurístico de la mente, que comprende los sentidos, el entendimiento y la razón; en un sentido pragmático, referido particularmente a la psicoterapia, el filósofo: e) afirmó que todas las acciones humanas se originan de 3 fuentes fundamentales: egoísmo, maldad y compasión; también especuló acerca del papel de la represión inconsciente en la génesis de las enfermedades mentales, y para terminar, f) enfatizó la ubicuidad del sufrimiento y la insaciabilidad del deseo, lo que inevitablemente lleva al egocentrismo. En este sentido, valoró la contemplación artística y de la naturaleza como una vía para disociar el conocimiento del deseo y así permitir el desarrollo de la compasión y el ascetismo. El filósofo lo consideraba la "negación de la voluntad" y un camino para la salvación y el bienestar individual. En la Psiquiatría contemporánea, esta propuesta metafísica puede reformularse como la promoción de la cooperación y de una austeridad sana, como un componente inespecífico de la mayoría de las psicoterapias y los modelos educativos. El pensamiento de Schopenhauer puede enriquecer la instrucción en Psiquiatría y el bienestar personal.


Subject(s)
Humans , Psychiatry , Work , Knowledge , Psychotherapy , Repression, Psychology , Stress, Psychological , Thinking , Models, Educational , Ethics , Anniversaries and Special Events
12.
Rev. psicanal ; 27(1): 157-167, Abril 2020.
Article in Portuguese | LILACS, INDEXPSI | ID: biblio-1248402

ABSTRACT

O artigo aborda a neurose obsessiva de acordo com a obra de Freud, usada como ponto inicial para a argumentação do autor, enfatizando a sua dinâmica metapsicológica. Com base na hipótese clínica de que o pensamento torna-se fonte de angústia, destaca o fato do recalque dos componentes sádicos da libido constituir o ponto de partida da neurose. O autor enfatiza que, como escreveu Freud, a luta defensiva é a sua principal característica, distinguindo-a das demais neuroses. Ele sugere que uma fragilidade da estrutura narcísica primária é uma das condições necessárias para a forma peculiar da apresentação da angústia e de suas defesas. Ao argumentar que o pensamento torna-se fonte de angústia, destaca as dificuldades técnicas resultantes e sustenta que o manejo da transferência representa a única solução clínica possível (AU)


Inspired by Freud's work, used as a starting point for the author's arguments, the paper addresses obsessive neurosis, emphasizing its metapsychological dynamics. It starts from the clinical hypothesis that thought turns into a source of angst. It underlines that the repression of the sadistic components of libido constitutes the starting point of neurosis. The author emphasizes that, as Freud has said, the defensive struggle is its main feature, differentiating it from the other neurosis. The author suggests that a frailty of the primary narcissistic structure is a necessary condition for the peculiar aspect on how angst and its defenses manifest themselves. Reasoning that thoughts become source of angst, he emphasizes the consequent technical difficulties, and advocates that managing transference represents the only effective clinical approach.


El artículo aborda la neurosis obsesiva inspirada en el trabajo de Freud, utilizada como punto de partida para el argumento del autor, enfatizando su dinámica metapsicológica. Partiendo de la hipótesis clínica de que el pensamiento se convierte en una fuente de angustia, destaca que la represión de los componentes sádicos de la libido constituye el punto de partida de la neurosis. El autor enfatiza que, como escribió Freud, la lucha defensiva es su característica principal, distinguiéndola de otras neurosis. Él sugiere que una debilidad en la estructura narcisista primaria es una de las condiciones necesarias para la forma peculiar de la presentación de la angustia y sus defensas. Argumentando que el pensamiento se convierte en una fuente de angustia, destaca las dificultades técnicas resultantes y sostiene que el manejo de la transferencia representa la única solución clínica posible


Subject(s)
Neurotic Disorders , Repression, Psychology
13.
Journal of Breast Cancer ; : 20-35, 2020.
Article in English | WPRIM | ID: wpr-811199

ABSTRACT

PURPOSE: C-terminal binding protein 1 (CtBP1) is a transcriptional co-repressor that is overexpressed in many cancers. CtBP1 transcriptionally represses a broad array of tumor suppressors, which promotes cancer cell proliferation, migration, invasion, and resistance to apoptosis. Recent studies have demonstrated that CtBP1 is a potential target for cancer therapy. This study was designed to screen for compounds that potentially target CtBP1.METHODS: Using a structure-based virtual screening for CtBP1 inhibitors, we found protocatechuic aldehyde (PA), a natural compound found in the root of a traditional Chinese herb, Salvia miltiorrhiza, that directly binds to CtBP1. Microscale thermophoresis assay was performed to determine whether PA and CtBP1 directly bind to each other. Further, clustered regularly interspaced short palindromic repeats associated Cas9 nuclease-mediated CtBP1 knockout in breast cancer cells was used to validate the CtBP1 targeting specificity of PA.RESULTS: Functional studies showed that PA repressed the proliferation and migration of breast cancer cells. Furthermore, PA elevated the expression of the downstream targets of CtBP1, p21 and E-cadherin, and decreased CtBP1 binding affinity for the promoter regions of p21 and E-cadherin in breast cancer cells. However, PA did not affect the expression of p21 and E-cadherin in the CtBP1 knockout breast cancer cells. In addition, the CtBP1 knockout breast cancer cells showed resistance to PA-induced repression of proliferation and migration.CONCLUSION: Our findings demonstrated that PA directly bound to CtBP1 and inhibited the growth and migration of breast cancer cells through CtBP1 inhibition. Structural modifications of PA are further required to enhance its binding affinity and selectivity for CtBP1.


Subject(s)
Humans , Apoptosis , Asian People , Breast Neoplasms , Breast , Cadherins , Carrier Proteins , Cell Proliferation , Clustered Regularly Interspaced Short Palindromic Repeats , Mass Screening , Promoter Regions, Genetic , Repression, Psychology , Salvia miltiorrhiza , Sensitivity and Specificity
14.
Rev. Subj. (Impr.) ; 19(3): 1-10, set.-dez. 2019.
Article in Portuguese | LILACS, INDEXPSI | ID: biblio-1092246

ABSTRACT

Freud descreveu, em seu trabalho "Inibição, sintoma e angústia" (1926/2014b), duas formas de inibição da ação: uma relacionada à evitação da reatualização de conflitos psíquicos, da instauração de um novo ato de recalcamento e da emissão de angústia-sinal (inibição específica); outra conexa a situações de empobrecimento de energia disponível no eu (inibição generalizada). Os autores do presente artigo buscam aprofundar a descrição do mecanismo metapsicológico do segundo tipo de inibição - ao qual propõem a designação alternativa de "inibição econômica" -, baseando-se, para isso, no modelo de trauma desenvolvido por Freud em "Além do princípio do prazer" (1920/2010c). Essa forma de inibição é uma medida emergencial do eu cuja finalidade é alterar o gerenciamento de energia em favor de tarefas psíquicas prioritárias, que demandam elevado custo energético para sua realização.


In the work "Inhibition, Symptom and Anguish" (1926/2014b), Freud described two forms of action inhibition: one related to the avoidance of the re-actualization of psychic conflicts, the establishment of a new act of repression and the emission of signal anguish ( specific inhibition); another related to situations of energy depletion available in the self (generalized inhibition). The authors of this paper seek to deepen the description of the meta-psychological mechanism of the second type of inhibition - which they propose the alternative designation of "economic inhibition" - based on Freud's trauma model in "Beyond the Principle of pleasure" (1920/2010c). This form of inhibition is an emergency measure of the self whose purpose is to alter energy management in favor of priority psychic tasks that demand a high energy cost to accomplish.


Freud describió, en su trabajo "Inhibición, síntoma y angustia" (1926/2014b), dos formas de inhibición de la acción: una relacionada a la evitación de la reactualización de conflictos psíquicos, de la implantación de un nuevo acto de represión y de la emisión de señal de angustia (inhibición específica); otra en conexión con situaciones de empobrecimiento de energía disponible en el yo (inhibición generalizada). Los autores de este trabajo buscan profundizar la descripción del mecanismo metapsicológico del segundo tipo de inhibición - a lo cual proponen la designación alternativa de "inhibición económica"-, basándose, para eso, en el modelo de trauma desarrollado por Freud en "Más allá del principio del placer" (1920/2010c). Esta forma de inhibición es una medida de emergencia del yo cuya finalidad es alterar la gestión de energía en favor de tareas psíquicas prioritarias, que demandan elevado coste energético para su realización.


Freud a décrit dans son œuvre "Inhibition, Symptôme et Angoisse" (1926/2014b) deux catégories de l'inhibition de l'action: une liée à éviter réactualiser les conflits psychiques, de l'instauration d'un nouveau acte de répression et de l'émission de l'angoisse-signe (inhibition spécifique); l'autre liée aux situations appauvrissement de l'énergie disponible en soi (inhibition généralisée). Les auteurs du présent article cherchent approfondir la description du mécanisme métapsychologie du second type d'inhibition - auquel ils proposent la désignation alternative « inhibition économique ¼. À cause de cela, ils se son basés dans le modèle de traumatisme développé par Freud dans «Au delà du principe de plaisir ¼ (1920/2010c). Cette forme d'inhibition est une mesure d'urgence chez le soi dont le but est de modifier la gestion de l'énergie en faveur de tâches psychiques prioritaires, lesquelles nécessitent un coût énergétique élevé.


Subject(s)
Inhibition, Psychological , Repression, Psychology , Combat Disorders
15.
Rev. latinoam. psicol ; 51(2): 66-73, May-Aug. 2019. graf
Article in Spanish | LILACS, COLNAL | ID: biblio-1094033

ABSTRACT

Resumen Este artículo analiza la represión social como mecanismo de los dispositivos de control estatal para contrarrestar el malestar y la rebeldía juvenil en la Universidad Nacional de Colombia, la Universidad de Antioquia (UdeA) y la Universidad Industrial de Santander (UIS), desde 1981 hasta 1991. El análisis utilizó variables como violencia pública, violencia privada y protesta social. Este artículo maneja una metodología cualitativa; para ello, realizó entrevistas semiestructura-das a 35 personas, siguiendo un modelo narrativo, las cuales entre 1981-1991 fueron activistas políticos o simpatizantes de izquierda en las universidades mencionadas. Tal información fue correlacionada con las estadísticas de asesinatos y desapariciones del Centro Nacional de Memoria Histórica y de Vidas Silenciadas. Los hallazgos evidencian una represión urbana dirigida a estudiantes simpatizantes de la izquierda; de otro lado, dicha represión es significativa en espacialidades específicas. Lo anterior revalida la tesis según la cual la violencia, más que un efecto nacional, debe ser entendida como una causa local. El presente artículo contribuye a los estudios psicosociales de la violencia, pues pone en consideración que esta no es solamente un síntoma irracional, sino que, por el contrario, hace parte probablemente de una red consciente de represión personal y colectiva, orquestada como mecanismo conductual por el establishment.


Abstract This article analyzes social repression as a mechanism of state control devices to counteract the malaise and youthful rebellion in the National University of Colombia (UNAL), Antioquia (UdeA) and Industrial de Santander (UIS), from 1981 to 1991. The hypothesis is based on the theory of devices delineated by Michel Foucault and Giorgio Agamben in the transition from disciplinary societies to control societies. The analysis used variables such as public violence, private violence and social protest. This article handles a qualitative research methodology, for this, semi-structured interviews were conducted following a narrative model to thirty-five people, who between 1981-1991 were political activists or sympathizers of the left in previously mentioned universities; this information was correlated with the statistics of murders and disappearances of the National Center of Historical Memory and Silenced Lives. The findings show an urban repression directed mostly at sympathetic students of the left, on the other hand, this repression is significant in specific spatialities, which revalidates that violence rather than a national effect should be understood as a local cause. This article contributes to the psychosocial studies of violence, since it considers that it is not only an irrational symptom, on the contrary, it is likely to be part of a conscious network of personal and collective repression orchestrated as a behavioral mechanism by the establishment.


Subject(s)
Humans , Male , Female , Adult , Repression, Psychology , Social Control, Formal , Adolescent , Universities , Violence , Movement
16.
Estud. pesqui. psicol. (Impr.) ; 19(1): 187-205, jan.-abr. 2019.
Article in Portuguese | LILACS, INDEXPSI | ID: biblio-999356

ABSTRACT

A proibição do uso de drogas é um fenômeno essencialmente moderno, pautada numa postura intolerante e repressiva, um discurso de terror e punição que acaba por gerar violência e sofrimento para os usuários de substâncias ilícitas. Mostramos por meio de alguns teóricos o quanto os discursos e práticas ideologizados colocam as pessoas que utilizam drogas ilícitas como inimigos sociais sem considerar as contradições e riscos a que são submetidos cotidianamente, além de ir em direção oposta à tendência à atualização e ao potencial do indivíduo. O presente estudo se caracteriza por ser uma pesquisa bibliográfica, de cunho qualitativo. A literatura consultada sugere que o fenômeno das drogas é complexo e se configura como pertencente à condição humana, bem como o único meio de contribuir com a ampliação de sentidos existências é por meio da política de Redução de Danos.(AU)


The prohibition of drug use is an essentially modern phenomeno, based on an intolerant and repressive stance, a discourse of terror and punishment, which generates violence and suffering to users of illicit substances. We have shown through some theorists how ideological discourses and practices place people who use illicit drugs as social enemies without considering the contradictions and risks they are submitted daily, in addition to going in the opposite direction as to the tendency to update and the potential of the individual. The present study is characterized by a qualitative bibliographical research. With the elaboration of such a study it is able to perceive that the phenomenon of drugs is complex, and is configured as belonging to the condition, as well as the only way to contribute to the expansion of existent senses is through the Harm Reduction policy.(AU)


La prohibición del uso de drogas es un fenómeno esencialmente moderno, pautado en una postura intolerante y represiva, un discurso de terror y castigo que acaba por generar violencia y sufrimiento para los usuarios de sustancias ilícitas. Mostramos por medio de algunos teóricos cuánto los discursos y prácticas ideologizados colocan a las personas que utilizan drogas ilícitas como enemigos sociales sin considerar las contradicciones y riesgos a que son sometidos cotidianamente, además de ir en dirección opuesta a la tendencia a la actualización y al potencial del individuo. El presente estudio se caracteriza por ser una investigación bibliográfica, de cuño cualitativo. La literatura consultada sugiere que el fenómeno de las drogas es complejo, y se configura como perteneciente a la condición humana, así como el único medio de contribuir con la ampliación de sentidos existencias es por medio de la política de Reducción de Daños.(AU)


Subject(s)
Humans , Violence/psychology , Substance-Related Disorders , Harm Reduction , Psychotropic Drugs , Public Policy , Punishment/psychology , Repression, Psychology , Stress, Psychological/psychology , Pharmaceutical Preparations , Drug Trafficking
17.
Biomolecules & Therapeutics ; : 231-239, 2019.
Article in English | WPRIM | ID: wpr-739653

ABSTRACT

Suppressor of Variegation 3–9 Homolog 2 (SUV39H2) methylates the lysine 9 residue of histone H3 and induces heterochromatin formation, resulting in transcriptional repression or silencing of target genes. SUV39H1 and SUV39H2 have a role in embryonic development, and SUV39H1 was shown to suppress cell cycle progression associated with Rb. However, the function of human SUV39H2 has not been extensively studied. We observed that forced expression of SUV39H2 decreased cell proliferation by inducing G1 cell cycle arrest. In addition, SUV39H2 was degraded through the ubiquitin-proteasomal pathway. Using yeast two-hybrid screening to address the degradation mechanism and function of SUV39H2, we identified translationally controlled tumor protein (TCTP) as an SUV39H2-interacting molecule. Mapping of the interacting regions indicated that the N-terminal 60 amino acids (aa) of full-length SUV39H2 and the C-terminus of TCTP (120–172 aa) were critical for binding. The interaction of SUV39H2 and TCTP was further confirmed by co-immunoprecipitation and immunofluorescence staining for colocalization. Moreover, depletion of TCTP by RNAi led to up-regulation of SUV39H2 protein, while TCTP overexpression reduced SUV39H2 protein level. The half-life of SUV39H2 protein was significantly extended upon TCTP depletion. These results clearly indicate that TCTP negatively regulates the expression of SUV39H2 post-translationally. Furthermore, SUV39H2 induced apoptotic cell death in TCTP-knockdown cells. Taken together, we identified SUV39H2, as a novel target protein of TCTP and demonstrated that SUV39H2 regulates cell proliferation of lung cancer cells.


Subject(s)
Female , Humans , Pregnancy , Amino Acids , Apoptosis , Carrier Proteins , Cell Cycle , Cell Death , Cell Proliferation , Embryonic Development , Fluorescent Antibody Technique , G1 Phase Cell Cycle Checkpoints , Half-Life , Heterochromatin , Histones , Immunoprecipitation , Lung Neoplasms , Lysine , Mass Screening , Repression, Psychology , RNA Interference , Up-Regulation , Yeasts
18.
Yonsei Medical Journal ; : 898-904, 2019.
Article in English | WPRIM | ID: wpr-762043

ABSTRACT

PURPOSE: Sonic hedgehog (Shh) signaling pathway is known to play a crucial role in carcinogenesis in various malignancies, including lung cancer regarding tumorigenesis, angiogenesis, and cellular differentiation. The aim of this study was to investigate the value of components of Shh pathway as a prognostic marker in extensive stage small cell lung cancer (ES-SCLC) patients. MATERIALS AND METHODS: We retrospectively analyzed data of 36 patients who were diagnosed with ES-SCLC between 2008 and 2012 at a single center. We performed immuo-histochemistry for glioma-associated oncogene homolog zinc finger protein 1 (Gli1), patched, Shh, and Ptch-mediated repression of smoothened (Smo) proteins using formalin-fixed, paraffin-embedded tissue derived from primary tumors. We then conducted survival analysis to evaluate the prognostic impact of these markers. RESULTS: All 36 patients received platinum-based doublet chemotherapy. The median progression free survival and median overall survival were 6.9 months [95% confidence interval (CI), 6.5–7.3] and 11.7 months (95% CI, 9.1–14.3), respectively. The overall response rate was 84%. Of the 36 tissue specimens examined, over-expression of Gli1, Patched, Shh, and Smo was found in 12 (33.3%), five (13.9%), five (13.9%), and six (16.7%) cases, respectively. We found that high expression of Shh was associated with worse progression free survival (6.3 vs. 7.6 months, p=0.005) and overall survival (9.2 vs. 12.0 months, p=0.039) by both univariate and multivariate analyses, whereas other markers were not related to patient prognosis. CONCLUSION: A high proportion of small cell lung cancer tumors express proteins related to Shh pathway, and over-expression of Shh is correlated with poor prognosis.


Subject(s)
Humans , Carcinogenesis , Disease-Free Survival , Drug Therapy , Hedgehog Proteins , Hedgehogs , Lung Neoplasms , Multivariate Analysis , Oncogenes , Prognosis , Repression, Psychology , Retrospective Studies , Small Cell Lung Carcinoma , Zinc Fingers
19.
The Korean Journal of Physiology and Pharmacology ; : 449-458, 2019.
Article in English | WPRIM | ID: wpr-761819

ABSTRACT

Retinoblastoma (Rb) is one of the most common eye malignancies occur in childhood. The crucial roles of non-coding RNAs, particularly long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), have been widely reported in Rb progression. In the present study, we found the expression of lncRNA T-cell leukemia/lymphoma 6 (TCL6) was significantly downregulated in Rb tissues and cell lines. Knockdown of lncRNA TCL6 promoted cell proliferation while reduced cell apoptosis in Rb cells. Moreover, lncRNA TCL6 serves as a sponge for miR-21, a previously-reported oncogenic miRNA in Rb, by direct targeting to negatively regulated miR-21 expression, therefore modulating Rb proliferation through miR-21. TCL6 overexpression inhibited Rb cell proliferation while miR-21 overexpression exerted an opposing effect; the effect of TCL6 overexpression was partially attenuated by miR-21 overexpression. PTEN/PI3K/AKT signaling pathway was involved in lncRNA TCL6/miR-21 axis modulating Rb cell proliferation. Taken together, lncRNA TCL6 serves as a tumor suppressor by acting as a sponge for miR-21 to counteract miR-21-mediated PTEN repression.


Subject(s)
Apoptosis , Cell Line , Cell Proliferation , MicroRNAs , Porifera , Repression, Psychology , Retinoblastoma , RNA, Long Noncoding , RNA, Untranslated , T-Lymphocytes
20.
The Korean Journal of Physiology and Pharmacology ; : 21-28, 2019.
Article in English | WPRIM | ID: wpr-728029

ABSTRACT

Swertiamarin (STM) is an iridoid compound that is present in the Gentianaceae swertia genus. Here we investigated antiapoptotic effects of STM on carbon tetrachloride (CCl₄)-induced liver injury and its possible mechanisms. Adult male Sprague Dawley rats were randomly divided into a control group, an STM 200 mg/kg group, a CCl₄ group, a CCl₄+STM 100 mg/kg group, and a CCl₄+STM 200 mg/kg group. Rats in experimental groups were subcutaneously injected with 40% CCl₄ twice weekly for 8 weeks. STM (100 and 200 mg/kg per day) was orally given to experimental rats by gavage for 8 consecutive weeks. Hepatocyte apoptosis was determined by TUNEL assay and the expression levels of Bcl-2, Bax, and cleaved caspase-3 proteins were evaluated by western blot analysis. The expression of TGF-β1, collagen I, collagen III, CTGF and fibronectin mRNA were estimated by qRT-PCR. The results showed that STM significantly reduced the number of TUNEL-positive cells compared with the CCl₄ group. The levels of Bax and cleaved caspase-3 proteins, and TGF-β1, collagen I, collagen III, CTGF, and fibronectin mRNA were significantly reduced by STM compared with the CCl₄ group. In addition, STM markedly abrogated the repression of Bcl-2 by CCl₄. STM also attenuated the activation of the PI3K/Akt pathway in the liver. These results suggested that STM ameliorated CCl₄-induced hepatocyte apoptosis in rats.


Subject(s)
Adult , Animals , Humans , Male , Rats , Apoptosis , Blotting, Western , Carbon Tetrachloride , Carbon , Caspase 3 , Collagen , Fibronectins , Gentianaceae , Hepatocytes , In Situ Nick-End Labeling , Liver , Rats, Sprague-Dawley , Repression, Psychology , RNA, Messenger , Swertia
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